ON HELIX 2020: Transforming new medicine discovery Registration LIVE This One Nucleus flagship Cambridge conference ON Helix brings our network together to present and discuss the main innovation and technology trends in therapeutics research and development. The impact of new science and the challenges faced in translating them in new healthcare products is debated through a mix of plenary sessions focusing on innovation, parallel workshops and networking. Throughout the one and a half-days, the plenary sessions will see speakers address the latest innovations and technologies in an evolving therapeutic environment whilst the parallel workshops are dedicated to some of their business challenges as detailed below. Full details of the conference can be found at onhelix.com Programme ON Helix Keynote Plenary Sessions: Transforming R&D with Patients Cambridge Biotech – Back to the Future II The Business Models of Therapeutic Research Biotech Rising Stars Showcase ON Helix Programme Session: Five, one hour sessions will develop various elements of how Life Science R&D models are evolving with experts’ presentations and panel discussions. Topics will include: Transforming Drugs with Diagnostics Unlocking the Undruggable Space Surpassing Current Pre-Clinical Models Manufacturing New Modalities Backing Health Claims in a Sophisticated Therapeutics Game ON Helix Workshops: In parallel to the five programme sessions, our network experts will run workshops dedicated to the business challenges of our evolving R&D models: Navigating Research Funding Medical Communication of the Future Facilities to Support Evolving R&D Models Multi-Disciplinarity vs Expertise – the 21st Century Scientist Building the Dream Preclinical Dataset On Helix Detailed programme: Day One |13 July 2020 12.30  Registration 13:30  Welcome 13:45  Keynote Speakers Whether it’s the rise of precision medicine or the increase of technology components in healthcare delivery these presentations will review their impact on Research and Development in the pharmaceutical industry. Opening panel discussion – Transforming R&D with Patients The patients we’re all are, are invaluable resources to improve the way we approach R&D. This session should highlight some examples of this and how patients are getting back at the heart of R&D. 15:30  Tea/Coffee Break 16:00 Transforming Drugs with Diagnostics – Plenary Session With the promise for earlier interventions and better patients’ segmentation, diagnostics have the potential to disturb the way therapeutics are delivered. This session will showcase three examples of diagnostics influence in therapeutics drug development. 16:00  Workshop – Thinking medical communication early enough. For your investors, collaborators and own interest. 17:00  Cambridge Biotech: Back to the Future II Nick McCooke 18:15  Drinks Reception 19:30 Close   Day Two |14 July 2020 08:30  Registration 08:55  Welcome back 09:00  Keynote speaker A case study of a successful new modality drug development. Akshay Vaishnaw, President Research and Development Alnylam Panel Discussion – The Business Models of Research New modalities, sophistication of data health claims, global and more complex markets, pharmas business models are evolving but what about their R&D models? What will be key to lead tomorrow’s therapeutics development? This panel session will discuss some elements of answer on: Strategic approaches in therapeutic areas from niche to cross indications The specialisation in technologies elements and how data is taking a leading role in R&D 10:15  Tea/Coffee Break 10:45  Unlocking the Undruggable Space – Plenary Session A session to review current limitations in targets addressed and presentations on solutions to unlock them. Benedict Cross, Phoremost 10:45  Workshop – Facilities to support growth 11:45  Surpassing Current pre-clinical Models – Plenary Session A session to review the current progresses and limitations of innovative pre-clinical models. 11:45  Workshop – PMultidisciplinarity vs Expertise – the 21st century scientist 12:45 – Lunch 13:45  Manufacturing New Modalities – Plenary Session A session to review what will be needed to shift paradigm in therapeutics development especially in the cell and gene therapy space 13:45  Workshop – Early stage research – what public funding is available and how to access it. 14:45  Backing Health Claims in a Sophisticated Therapeutics Game – Plenary Session With a more diverse and costly pool of therapeutics, how to build more robust evidence to back health claim for regulatory, payers and patients. 14:45  Workshop – Your pre-clinical dataset in a nutshell 15:45  Tea/Coffee Break 16:15  Closing panel – Who Will Lead the Future of New Modalities? We’re seeing an increasing fight for acquisition from pharma and service companies to lead next generation therapeutics development, this panel will review some of these big deals and how they may impact the industry. Please contact aline@onenucleus.com with any questions regarding the 2020 programme Venue: Granta Centre, Granta Park, Cambridge onhelix.com Follow us on Twitter: @OneNucleus and use #ONHelix20